23. 03. 2014 18:59
|
Registrierungsdatum: 13 Jahre zuvor
Beiträge: 683
|
Melatonin attenuates antipsychotic metabolic effects
"Results
The melatonin group showed a decrease in diastolic blood pressure
(5.1 versus 1.1 mmHg for placebo, p = 0.003) and attenuated weight gain
(1.5 versus 2.2 kg for placebo, F = 4.512, p = 0.040) compared to the placebo group.
The strong beneficial metabolic effects of melatonin in comparison to placebo on fat mass
(0.2 versus 2.7 kg, respectively, p = 0.032) and diastolic blood pressure
(5.7 versus 5.5 mmHg, respectively, p = 0.001) were observed in the bipolar disorder
and not in the schizophrenia group. No adverse events were reported.
Conclusions
Our results show that melatonin is effective in attenuating SGAs' adverse metabolic
effects, particularly in bipolar disorder. The clinical findings allow us to propose
that SGAs may disturb a centrally mediated metabolic balance that causes
adverse metabolic effects and that nightly administration of Melatonin
helps to restore. Melatonin could become a safe and cost-effective
therapeutic option to attenuate or prevent SGA metabolic effects."
Mit freundlichen Grüßen
Phineas
-------------------------------------------------------------------------------------------------------
Phineas, Angehöriger und Trockennasenprimat. Laut meiner Frau einer von den 2 grummeligen Opas aus der Muppetshow.
Zu selten gelesen:
Testing Treatments- Wo ist der Beweis?